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Evening primrose (Oenothera biennis) oil (EPO) contains an omega-6 essential fatty acid, gamma-linolenic acid (GLA), which is believed to be the active ingredient. It is theorized that primrose oil may be helpful in patients with MS based on laboratory studies. Limited evidence is available in humans, and a firm conclusion is not possible at this time.

Several reports describe seizures in individuals taking evening primrose oil (EPO). Some of these seizures developed in people with a previous seizure disorder, or in individuals taking EPO in combination with anesthetics. Based on these reports, people with seizure disorders should not take EPO. EPO should be used cautiously with drugs used to treat mental illness such as chlorpromazine (Thorazine®), thioridazine (Mellaril®), trifluoperazine (Stelazine®), or fluphenazine (Prolixin®), due to an increased risk of seizure. Patients who plan to undergo surgery requiring anesthesia should stop taking EPO two weeks ahead of time because of the possibility of seizure.

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