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Choline is an essential nutrient related to the water-soluble B-complex vitamins, folate, pyridoxine, and vitamin B12, and to the essential amino acid methionine. It is synthesized in the body as well as consumed in the diet. The largest dietary source of choline is egg yolk. Choline can also be found in high amounts in liver, peanuts, fish, milk, brewer's yeast, wheat germ, soy beans, bottle gourd fruit, fenugreek leaves, shepherd's purse herb, Brazil nuts, dandelion flowers, poppy seeds, mung and other beans, and a variety of meats and vegetables, including cabbage and cauliflower. Choline is a major building block of lecithin. Choline is a precursor to acetylcholine, a chemical used to transfer nerve impulses. Therefore, choline is believed to have neurological effects. Early treatment with choline alphoscerate (CA), a substrate of phosphatidylcholine and a carrier of choline, was shown to be safe. Additional study is needed to confirm these findings. It is best to avoid choline in individuals with a known allergy or hypersensitivity to choline, lecithin, or phosphatidylcholine.
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