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Podophyllum rhizomes have a long medicinal history among native North American tribes who used a rhizome powder as a laxative or to treat infections with worms or parasites. A topical poultice of the powder was also used to treat warts and tumorous growths on the skin. Preliminary research suggests that podophyllum may be helpful for rheumatoid arthritis. Research is limited due to the possible adverse effects like severe diarrhea associated with taking podophyllum by mouth. However, additional research is needed before a firm conclusion can be drawn. Avoid if allergic/hypersensitive to podophyllum or the Berberidaceae family. Podophyllum, when applied topically, may be absorbed through the skin and cause irritation of the stomach and intestines. Podophyllum toxicity may cause heart palpitations and blood pressure changes, muscle paralysis, difficulty walking, confusion, and convulsions. Using podophyllum and laxatives may result in dehydration and electrolyte depletion. Read more
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Overview
