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Arginine: L-arginine, or arginine, is considered a semi-essential amino acid because although it is normally synthesized in sufficient amounts by the body, supplementation is sometimes required. Early studies found that men with low nitrate levels in their blood or urine, which is a cause of ED, may find arginine supplements to be useful for managing erectile dysfunction (ED). A randomized, controlled clinical trial reported improvements in patients with ED following the use of a combination of L-arginine, glutamate, and yohimbine hydrochloride. Notably, yohimbine hydrochloride is an U.S. Food and Drug Administration (FDA) approved drug therapy for ED, and the effects caused by arginine alone in this combination therapy are difficult to determine. It is not clear what doses of arginine may be safe or effective in treating this condition, and comparisons have not been made with other agents used for ED. Larger, high-quality studies are needed. Read more
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