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Comfrey
: In vitro studies have found that comfrey may have anti-inflammatory effects. Clinical trials investigating topical application of comfrey-containing creams have found significant reductions in inflammation and pain associated with sprains and muscle injuries. Overall, these studies have been well designed although some improvements in reporting are needed.Avoid if allergic or hypersensitive to comfrey, its constituents or members of the Boraginaceae family. Avoid oral comfrey due to hepatotoxic (liver toxicity) and carcinogenic (cancer-causing) pyrrolizidine alkaloids. Oral use has caused death. Avoid topical comfrey on broken skin due to hepatotoxic and carcinogenic pyrrolizidine alkaloids. Avoid topical comfrey in individuals with or at risk for hepatic disorders, cancer or immune disorders. Use topical creams containing comfrey cautiously if taking anti-inflammatory medications or cytochrome P450 3A4-inducing agents. Read more
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