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Arginine: In patients with inborn errors of urea synthesis, high blood ammonia levels may occur due to a deficiency or absence of necessary enzymes in the urea cycle. Arginine is an essential amino acid in the urea cycle that may be helpful by providing a necessary component of the cycle, but should be avoided in patients with hyperargininemia (high arginine levels) and arginase deficiency. In arginase deficiency, the enzyme needed to break down arginine is absent or deficient and supplementing with arginine will worsen the disease. The use of arginine for a urea cycle disorder should be supervised by a qualified healthcare professional.Arginine should be avoided if there is a history of stroke, liver disease, or kidney disease. Avoid if pregnant or breastfeeding. Use caution if taking blood-thinning drugs (like warfarin or Coumadin ®) and blood pressure drugs or herbs or supplements with similar effects. It is important to check blood potassium levels. Read more
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