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Summary:Boneset (Eupatorium perfoliatum) is native to eastern North America and was used by Native Americans to treat fevers, including dengue fever and malaria. Today, boneset is used primarily in homeopathic medicine for fevers, influenza, digestive problems, and liver disorders. Products containing boneset have been placed in the "Herbs of Undefined Safety" category by the U.S. Food and Drug Administration (FDA).Scientific Evidence:Uses These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. Grade* Colds/flu C* | rVita Treatment Chart for Boneset |