Bacopa: Bacopa (Bacopa monnieri) is commonly called "brahmi" and is used in the Ayurvedic system of medicine in India. Although bacopa is traditionally used for anxiety, high-quality clinical trials are lacking. The one weak study below found some evidence that bacopa reduces clinical anxiety. However, more independent research is needed. Caution is advised when taking bacopa supplements as numerous adverse effects including heart palpitations are possible.
Gotu kola: In the traditional Indian system of Ayurvedic medicine, gotu kola is said to develop the crown chakra, the energy center at the top of the head, and to balance the right and left hemispheres of the brain. It has traditionally been used by yogis as a food for meditation. Animal research has demonstrated anxiolytic (anxiety reducing) properties of gotu kola, but human studies are lacking. A single randomized trial assessing the effects of gotu kola on startle responses in healthy (non-anxious) individuals has reported some benefits. These preliminary findings are promising, although further research should be performed. Gotu kola is not related to the cola nut, and does not contain caffeine. Gotu kola is generally reported as safe when used in humans for short term use.
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