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Bone disease: Fanconi syndrome may lead to rickets in children and osteomalacia in adults. Both of these conditions cause the bones to become softer and less dense than normal. Rickets may lead to bone deformities, stunted growth, and difficulty walking in children. Osteomalacia (rickets in adults) may cause severe bone pain and spontaneous bone fractures. Unlike rickets that is caused by poor nutrition, these conditions cannot be reversed with vitamin D supplementation. High blood pressure: Some patients with kidney disorders, such as glomerulonephritis, may develop high blood pressure. If the kidneys do not filter the blood properly, the extra fluid and waste in the blood vessels may cause high blood pressure. Having high blood pressure may worsen symptoms of kidney disease. This is because high blood pressure damages the blood vessels throughout the body, including the kidneys. Kidney failure: Patients with kidney disease, including focal segmental glomerulosclerosis (FSGS), glomerulonephritis, kidney cancer, and nephrotoxicity, may develop kidney failure. When this happens the kidneys are damaged beyond repair. Kidney failure is fatal unless treated with a kidney transplant. Symptoms may include altered mental status and advanced uremia (build up of waste in the blood due to severe kidney disease). Symptoms of uremia include nausea, vomiting, bleeding, and seizures.
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