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Good Scientific Evidence
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DHEA
]: The majority of clinical trials investigating the effect of DHEA (dehydroepiandrosterone) for systemic lupus erythematosus support its use as an adjunct treatment. Additional study is needed to confirm these results. Avoid if allergic to DHEA. Avoid with a history of seizures. Use cautiously in patients who have adrenal or thyroid disorders, history of heart disease, stroke, seizures or diabetes. Use cautiously with anticoagulants (blood thinners) or with drugs, herbs or supplements that treat diabetes, heart disease, seizure or stroke. Avoid if pregnant or breastfeeding.
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Unclear or Conflicting Scientific Evidence
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Gamma linolenic acid (GLA)
]: The results from two randomized, double–blind, clinical trials in a group of individuals with Sjögren's syndrome suggest that no to minimal improvements were noted. One study found minor improvements in the Schirmer–I–test (test that measures the quantity of tears), whereas the other did not. Further clinical trials are required in this group of patients before recommendations can be made. There are no reports of allergic reactions to GLA. Use cautiously with drugs that increase the risk of bleeding like anticoagulants and anti–platelet drugs. Avoid if pregnant or breastfeeding.
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