Diagnosis of Immune Reconstitution Inflammatory Syndrome

A working group in the AIDS CLINICAL TRIALS GROUP first proposed diagnostic criteria for IRIS. In June 2006, researchers confirmed that the criteria proposed could be used to diagnose IRIS in patients starting HIV treatment. Based on the criteria, a diagnosis can be made if the patient experiences new or worsening symptoms of an infection or inflammation after starting antiretroviral therapy, symptoms cannot be explained by a new infection or the expected course of an infection that was diagnosed previously and the patient experiences a decrease in viral load of at least 1 log₁₀.

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