Achondroplasia and Podophyllum Overview

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Podophyllum: Podophyllum rhizomes have a long history of medicinal use among native North American tribes who used the rhizome powder as a laxative or to treat infections with worms or parasites. A topical poultice of the powder was also used to treat warts and tumorous growths on the skin. Preliminary research suggests that podophyllum may be helpful for rheumatoid arthritis. Research is limited due to the possible adverse effects like severe diarrhea associated with taking podophyllum by mouth. However, additional research is needed before a firm conclusion can be made.

Avoid if allergic/hypersensitive to podophyllum or to members of the Berberidaceae family. Podophyllum, when applied topically, may be absorbed through the skin and cause irritation of the stomach and intestines. Podophyllum toxicity may cause heart palpitations and blood pressure changes, muscle paralysis, difficulty walking, confusion, and convulsions. Using podophyllum and laxatives may result in dehydration and electrolyte depletion. Use cautiously with arrhythmia, Crohn's disease, cardiovascular problems, gallbladder disease or gallstones, high blood pressure, irritable bowel syndrome, liver insufficiency, muscular disorders, neurologic disorders, psychosis, and kidney insufficiency. Use cautiously if taking antimiotic agents (e.g. vincristine), anti-psychotic agents, or laxatives. Avoid if pregnant or breastfeeding.

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