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- Interstitial nephritis causes mild to severe damage to the kidneys, and it may cause acute kidney failure. About 15% of kidney failure cases are related to acute interstitial nephritis.
- Patients with AIN typically experience nonspecific symptoms of acute renal failure, including oliguria (decreased urine production), malaise (general feeling of discomfort), anorexia, nausea and vomiting.
- Other symptoms of AIN may include abnormal urinary sediment (the urine normally contains a wide variety of formed elements called urinary sediment), generalized hypersensitivity syndrome, fever, rash, changes in mental status, swelling (in any part of the body), weight gain (from fluid retention) and blood in the urine.
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